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. 2020 Dec 13;599(2):667–676. doi: 10.1113/JP280397

Figure 4. Nicotinic receptor antagonists prevented optogenetic cholinergic LTP.

Figure 4

A, control experiments, showing LTP induced by optogenetic stimulation of cholinergic afferents (n = 12, P = 0.01, paired t test). Black filled symbols and error bars: mean ± SD. Red open symbols: data from one cell. Inset: average EPSPs before (pink) and 25−30 min after (red) pairing. B, DHβE (1 μm) did not prevent optogenetic LTP (n = 8, P = 0.039, paired t test). C, 10 nm MLA also failed to completely block LTP (n = 8, P = 0.018, paired t test). D, LTP was blocked when both 1 mm DHβE and 10 nm MLA were bath‐applied (comparison with controls: n = 11, P = 0.009, unpaired t test). Scale bars = 1 mV, 2 s. Stimulation artefacts have been removed for clarity. [Color figure can be viewed at wileyonlinelibrary.com]