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. 2020 Nov 9;60(2):726–730. doi: 10.1002/anie.202011157

Figure 2.

Figure 2

AT180‐phosphorylation blocks nucleation of MT filaments inside tau droplets. a) DIC and fluorescence microscopy of the growth of MTs from performed hTau40 (25 μm) droplets upon addition of tubulin (10 μm) and GTP; scale bars, 10 μm. b) Microscopy of pTau(Cdk2) droplets into which tubulin partitions but no MTs are formed in the presence of GTP; scale bars, 10 μm. c) LLPS of hTau40, hTau23 and hTau23 (T231E/S235E) and the assembly of tubulin into MTs in the case of the wild‐type proteins but not for the hTau23 mutant that mimics AT180‐phosphorylation. Scale bars, 10 μm.