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. 2020 Dec 4;26(72):17574–17580. doi: 10.1002/chem.202003852

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© 2020 The Authors. Published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effects of compound 20 (a), 21 (b), 22 (c) on cell viability of the prostate cancer cell line LnCAP and HEK293 as the control cell line. Cells were treated with increasing concentrations of compounds, with a final DMSO concentration of 0.5 vol %. Cell viability was measured by MTT assays. Results represent three independent experiments with four technical replicates each. Boxed molecule shows the electrochemically generated benzoxazinone backbone precursor for the synthesis of compounds 20, 21 and 22.