Table 3.

Model parameters for one‐compartment continuous learning models

	Unit	M1‐350	M1‐200	M1‐100	M1‐50(A)	M1‐50(B)	M1‐50(C)	M1‐50(D)	M1‐50(E)
N patients		350	200	100	50	50	50	50	50
N samples		1,549	814	452	249	208	243	178	314
N cmt		1	1	1	1	1	1	1	1
${\theta }_{\text{CL}}$	L/hr	3.98 (6.1%)	3.8 (9.5%)	3.53 (9.9%)	3.96	4.15 (15%)	3.32 (13%)	3.76	3.56
${\theta }_V$	L	87.7 (7.7%)	93.8 (11%)	80.1 (11%)	83.5	64.8 (20%)	76.1 (18%)	87	73
${\theta }_{\text{SCR}}$		0.648 (7.7%)	0.682 (12%)	0.679 (10%)	0.64	0.589 (21%)	0.766 (12%)	0.641	0.579
${\theta }_{\text{AGE}}$		0.0622 (36%)	0.0435 (66%)	0.0617 (59%)	0.0661	0.0814 (60%)	0.0486 (110%)	0.009	0.009
Prop.	%	0.261 (3.1%)	0.259 (4.4%)	0.284 (5.7%)	0.308	0.272 (5.1%)	0.242 (8.7%)	0.291	0.293
Add.	mg/L	1.68 (55%)	1.79 (67%)	2.08 (83%)	0.0105	0.477 (190%)	1.72 (160%)	0.0105	1.48
${\eta }_{\text{CL}}$		0.384 (4.3%)	0.368 (6.7%)	0.427 (7.4%)	0.344	0.424 (16%)	0.406 (12%)	0.453	0.381
${\eta }_{\text{CL}}\sim {\eta }_V$		0.626 (3.5%)	0.578 (5%)	0.866 (4.1%)	0.835	0.631 (8.7%)	0.388 (14%)	0.512	0.266
${\eta }_V$		0.555 (11%)	0.554 (17%)	0.487 (13%)	0.457	0.403 (16%)	0.561 (21%)	0.717	0.429

Values shown are estimates with the relative standard error (RSE) expressed in parentheses. Missing RSE values indicate the covariance step could not be performed in NONMEM.

SCR, serum creatinine; N _cmt, number of compartments in the training data set; N _patients, number of patients in the training data set; N _samples, number of vancomycin serum levels in the training data set.