Scheme 2.
Synthesis of dropropizine via cyclic carbonate 2 j. Reaction conditions: i) 23 °C, 1 h, H2O then NaOH/H2O, 75 °C, 15 min. ii) 5 mol % 8, 23 °C, 48 h, p(CO2)=1.0 MPa. iii) NaOH/H2O, 3 h, 23 °C. [a] 45 °C. [b] 45 °C, 24 h.
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