TABLE 1.
Patient characteristics
| Characteristics | HBeAg‐positive (n = 176) | HBeAg‐negative (n = 103) |
|---|---|---|
| Age at inclusion, years (median, IQR) | 32 (23‐41) | 41 (33‐50) |
| Male (n, %) | 135 (76.7) | 74 (71.8) |
| Race (n, %) | ||
| Caucasian | 116 (65.9) | 98 (95.1) |
| Asian | 43 (24.4) | 3 (2.9) |
| Other | 17 (9.7) | 2 (1.9) |
| HBV genotype (n, %) | ||
| A | 53 (30.1) | 15 (14.6) |
| B | 18 (10.2) | 0 (0) |
| C | 35 (19.9) | 2 (1.9) |
| D | 64 (36.5) | 81 (78.6) |
| Other | 6 (3.4) | 5 (4.9) |
| Study treatment (n, %) | ||
| PEG‐IFN mono | 86 (48.9) | 52 (50.5) |
| PEG‐IFN + LAM | 90 (51.1) | NA |
| PEG‐IFN + RBV | NA | 51 (49.5) |
| Laboratory results at baseline | ||
| HBV RNA a (mean, ±SD) | 6.8 (1.2) | 4.3 (0.9) |
| HBsAg b (mean, ±SD) | 4.4 (0.7) | 3.8 (0.5) |
| HBV DNA b (mean, ±SD) | 8.3 (1.0) | 6.0 (1.2) |
| HbcrAg c (mean, ±SD) | 8.3 (0.7) | 5.1 (1.2) |
Abbreviations: HBcrAg, hepatitis B core‐related antigen; HBeAg, hepatitis B e antigen; HBsAg, quantitative hepatitis B surface antigen; HBV, hepatitis B virus; IQR, interquartile range; LAM, lamivudine; n, number; NA, not applicable; PEG‐IFN, peginterferon; RBV, ribavirin; SD, standard deviation.
a
Logarithmic scale, copies/mL.
b
Logarithmic scale, IU/mL.
c
Logarithmic scale, U/mL.