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. 2020 Nov 26;40(3):690–711. doi: 10.1002/sim.8797

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© 2020 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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SIM-8797-FIG-0001-c — Regions of $θ$ values in which each of the Fixed Full population (FF), Fixed Subpopulation (FS), and optimal Adaptive Enrichment (AE) designs give the highest value of $E {G (θ, X)}$ [Color figure can be viewed at wileyonlinelibrary.com]