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. 2020 Nov 26;40(3):690–711. doi: 10.1002/sim.8797

TABLE 5.

Properties of the optimal adaptive enrichment (AE) design for different timings of the interim analysis τ when θ has the prior distribution given by (13) with μ1=12, μ2=4, σ12=σ22=25, and ρ=0.75. The interim analysis takes place after a fraction τ of the total sample has been observed

τ
P(1)
P(3)
P(Enrich)
E{G(θ,X)}
0.1 0.14 0.58 0.13 6.84
0.2 0.17 0.56 0.23 6.87
0.3 0.19 0.55 0.28 6.89
0.4 0.19 0.55 0.31 6.91
0.5 0.18 0.55 0.33 6.91
0.6 0.17 0.56 0.34 6.89
0.7 0.15 0.57 0.34 6.88
0.8 0.13 0.58 0.32 6.87
0.9 0.11 0.59 0.27 6.85