Table 2.
Variable | Depression | Anxiety | All psychiatric disorders |
---|---|---|---|
Cohort effect (RA vs. matched control)† | |||
When between‐person PSYC effect = 0 | 4.05 (3.94, 4.15) | 4.14 (4.04, 4.25) | 4.03 (3.93, 4.14) |
When between‐person PSYC effect = 1 | 6.02 (5.31, 6.74) | 6.84 (5.85, 7.84) | 6.03 (5.35, 6.71) |
When within‐person PSYC effect = 0 | 4.05 (3.94, 4.15) | 4.14 (4.04, 4.25) | 4.03 (3.93, 4.14) |
When within‐person PSYC effect = 1 | 3.98 (3.69, 4.27) | 4.31 (4.01, 4.61) | 3.95 (3.68, 4.20) |
Among RA cases† | |||
Between‐person effect PSYC | 11.18 (10.49, 11.87) | 13.25 (12.30, 14.20) | 10.92 (10.25, 11.58) |
Within‐person effect PSYC | 2.17 (1.92, 2.42) | 1.99 (1.73, 2.25) | 2.08 (1.85, 2.31) |
Among matches† | |||
Between‐person effect PSYC | 9.20 (8.93, 9.47) | 10.56 (10.18, 10.93) | 8.92 (8.67, 9.17) |
Within‐person effect PSYC | 2.23 (2.12, 2.35) | 1.82 (1.71, 1.93) | 2.17 (2.06, 2.27) |
Interaction between‐person (RA PSYC) | 1.98 (1.24, 2.72) | 2.70 (1.68, 3.72) | 2.00 (1.29, 2.70) |
Interaction within‐person (RA PSYC) | –0.06 (–0.33, 0.21) | 0.17 (–0.11, 0.45) | –0.09 (–0.34, 0.17) |
Year of diagnosis | 0.03 (0.03, 0.04) | 0.03 (0.022, 0.033) | 0.04 (0.03, 0.04) |
Disease duration, per year | –0.16 (–0.16, –0.15) | –0.16 (–0.16, –0.15) | –0.16 (–0.16, –0.15) |
Sex | |||
Female (male = reference) | 0.78 (0.72, 0.84) | 0.88 (0.81, 0.95) | 0.80 (0.74, 0.86) |
Age group | |||
18–24 | Ref. | Ref. | Ref. |
25–44 | 0.40 (0.26, 0.54) | 0.54 (0.40, 0.69) | 0.39 (0.25, 0.53) |
45–64 | 1.68 (1.54, 1.82) | 1.82 (1.68, 1.96) | 1.67 (1.53, 1.81) |
≥65 | 3.63 (3.48, 3.79) | 3.80 (3.64, 3.96) | 3.60 (3.44, 3.75) |
Region | |||
Urban (rural = reference) | 0.66 (0.60, 0.72) | 0.73 (0.66, 0.79) | 0.64 (0.580, 0.70) |
SEFI scores | |||
Quintile 1 (lowest) | 0.34 (0.24, 0.43) | 0.31 (0.20, 0.41) | 0.29 (0.20, 0.39) |
Quintile 2 | 0.14 (0.048, 0.24) | 0.21 (0.10, 0.31) | 0.13 (0.02, 0.22) |
Quintile 3 | 0.05 (–0.04, 0.15) | 0.11 (0.001, 0.21) | 0.04 (–0.05, 0.13) |
Quintile 4 | 0.07 (–0.03, 0.16) | 0.10 (–0.007, 0.20) | 0.06 (–0.05, 0.15) |
Quintile 5 (highest) | Ref. | Ref. | Ref. |
Linear trend SEFI scores | –0.075 (–0.096, –0.053) | –0.073 (–0.096, –0.049) | –0.065 (–0.087, –0.044) |
Count of ADGs (in prior year) | |||
0 | Ref. | Ref. | Ref. |
1 | 0.84 (0.80, 0.88) | 0.84 (0.81, 0.88) | 0.83 (0.80, 0.87) |
≥2 | 1.71 (1.63, 1.78) | 1.73 (1.66, 1.81) | 1.69 (1.62, 1.77) |
Values are the standardized mean difference (95% confidence interval). ADG = Aggregated Diagnosis Group; PSYC = active psychiatric comorbidity; RA = rheumatoid arthritis; Ref. = reference; SEFI = Socioeconomic Factor Index (values <0 indicate higher socioeconomic status).
Adjusted for sex, age group, region, year of diagnosis, disease duration, Socioeconomic Factor Index score, and Aggregated Diagnosis Groups. Between‐person and within‐person interaction terms included in the model.