Table 1.
eQTL results of rs3761124: during early brain development (UCLA), in nondiseased adult brain (CMC), and IDH1 wild‐type glioma (TCGA)
| CMC (N = 216) | UCLA (N = 219) | TCGA (N = 211) | |||||
|---|---|---|---|---|---|---|---|
| Gene ID | Gene Name | β (SE)† | p | β (SE) | p | β (SE) | p |
| ENSG00000197457.5 | STMN3 | −.07 (0.02) | 1.85 E−4 | −.04 (0.01) | 2.38 E−3 | −.04 (0.02) | 1.5 E−02 |
| ENSG00000125508.3 | SRMS | .01 (0.05) | 8.20 E−1 | N/Aa | N/Aa | .02 (0.05) | 7.50 E−1 |
| ENSG00000258366.3 | RTEL1 | −.01 (0.03) | 6.32 E−1 | .06 (0.02) | 1.56 E−2 | .06 (0.03) | 3.07 E−2 |
| ENSG00000026036.16 | RTEL1‐TNFRSF6B | .03 (0.03) | 2.70 E−1 | −.01 (0.03) | 6.89 E−1 | −.03 (0.03) | 3.20 E−1 |
| ENSG00000101216.6 | GMEB2 | −.01 (0.02) | 3.77 E−1 | −.06 (0.01) | 8.38 E−7 | .02 (0.01) | 1.23 E−1 |
Note: Listed results were of the candidate target genes identified by RT‐PCR assays after CRISPR−cas9 deletion of Enhancer 2. Values in bold represent genes that showed significant association with the functional SNP rs3761124 in the analyzed datasets.
Abbreviations: CMC, CommonMind Consortium; RT‐PCR, real‐time polymerase chain reaction; TCGA, The Cancer Genome Atlas; UCLA, University of California, Los Angeles.
a
This gene did not pass RNA‐seq Q/A in the UCLA dataset.