Table 2.
Circulatory miRNAs significantly associated with CT‐scan‐based fatty liver disease and serum liver enzymes
| miRNA ID | CT‐based FLD | Liver Enzymes | ||||||
|---|---|---|---|---|---|---|---|---|
| Dichotomous HU values | Continues HU values | GGT | ALP | |||||
| Beta | P value | Beta | P value | Beta | P value | Beta | P value | |
| miR‐193a‐5p | 1.86 | 2.02 × 10− 10a | −35.88 | 4.26 × 10−12a | 0.14 | 6.15 × 10−29a | 0.001 | 7.99 × 10−01 |
| miR‐4484 | 0.71 | 8.33 × 10−4 | −20.04 | 6.02 × 10−08a | 0.03 | 4.02 × 10−05a | 0.01 | 3.68 × 10−04 |
| miR‐1306‐5p | −0.60 | 3.15 × 10−01 | 55.59 | 1.21 × 10−07a | −0.09 | 6.45 × 10−05a | −0.02 | 1.12 × 10−01 |
| miR‐378a‐3p | 2.36 | 1.90 × 10−07 | −34.61 | 1.95 × 10−06a | 0.09 | 8.45 × 10−08a | −0.01 | 3.98 × 10−01 |
| miR‐6803‐5p | 0.70 | 2.68 × 10−02 | −27.96 | 2.01 × 10−07a | 0.05 | 6.31 × 10−05a | 0.01 | 1.03 × 10−02 |
| miR‐6870‐3p | −0.59 | 1.60 × 10−02 | 25.79 | 3.87 × 10−07a | −0.06 | 9.04 × 10−08a | −0.02 | 8.00 × 10−05a |
| miR‐3937 | −0.54 | 1.83 × 10−03 | 15.02 | 6.59 × 10−07 a | −0.03 | 1.90 × 10−06 a | −0.01 | 3.84 × 10−04 |
| miR‐122‐5p | 0.54 | 1.72 × 10−04 | −12.74 | 8.05 × 10−06 a | 0.14 | 2.39 × 10−116 a | 0.01 | 4.73 × 10−04 |
| miR‐422a | 2.01 | 9.87 × 10−06a | −25.07 | 6.09 × 10−05a | 0.06 | 9.71 × 10−06a | 0.002 | 7.37 × 10−01 |
| miR‐378d | 1.75 | 1.11 × 10−05a | −26.00 | 5.87 × 10−06a | 0.06 | 5.55 × 10−07a | −0.004 | 4.92 × 10−01 |
| miR‐187‐3p | −1.31 | 2.52 × 10−02 | 48.67 | 1.33 × 10−05a | −0.11 | 3.78 × 10−06a | −0.03 | 1.80 × 10−02 |
| miR‐6809‐5p | −0.73 | 5.51 × 10−02 | 34.03 | 1.61 × 10−05a | −0.08 | 1.45 × 10−06a | −0.01 | 1.11 × 10−01 |
| miR‐193b‐3p | 1.01 | 2.70 × 10−03 | −23.17 | 2.77 × 10−05 a | 0.11 | 2.01 × 10−21a | −0.001 | 7.85 × 10−01 |
| miR‐4713‐3p | −0.55 | 1.02 × 10−02 | 16.96 | 2.80 × 10−05a | −0.03 | 8.53 × 10−04 | ‐0.01 | 1.13 × 10−02 |
| miR‐320d | 1.16 | 2.87 × 10−05a | −14.30 | 4.54 × 10−03 | 0.02 | 1.72 × 10−01 | 0.004 | 4.10 × 10−01 |
| miR‐34b‐3p | −0.76 | 8.88 × 10−02 | 30.06 | 6.27 × 10−05a | −0.06 | 1.79 × 10−04 | −0.01 | 3.41 × 10−01 |
| miR‐378e | 1.64 | 6.88 × 10−05a | −21.54 | 6.86 × 10−04 | 0.06 | 3.13 × 10−05a | −0.01 | 4.42 × 10−01 |
Model 2: adjusted for age, sex, waist circumference, ever smoking, alcohol consumption, hypertension, diabetes mellitus and serum HDL cholesterol.
The table is sorted based on Bonferroni‐corrected P value association of miRNAs with dichotomous or continues Hounsfield Unit values in model 2.
The Bonferroni‐corrected significance threshold is P < 8.46 × 10−5 (0.05/591 miRNAs). The P values surpassing the significance threshold are “a”.
Abbreviations: ALP, Alkaline phosphatase; FLD, fatty liver disease; GGT, Gamma‐glutamyl transferase; HU, Hounsfield Unit; miRNA, microRNA.