FIGURE 9.

Structures of farnesylated or geranylgeranylated Ras protein and geranylgeranylated Rab protein. (a) FTase or GGTase‐I, a Zn²⁺‐dependent prenyltransferase, catalyzes the transfer of farnesyl diphosphate or geranylgeranyl diphosphate (GGPP) to a conserved cysteine residue in a CaaX motif of Ras protein. (b) Two GGPP molecules can be transferred by GGTase‐II to two conserved cysteine residues in the consensus CCXX region located at the C‐terminus of Rab protein. (c) Structures of six protein prenylation inhibitors investigated in clinical trials