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. Author manuscript; available in PMC: 2021 Jan 27.
Published in final edited form as: Cell Rep. 2021 Jan 5;34(1):108597. doi: 10.1016/j.celrep.2020.108597

Figure 1. The Mechanism Underlying CSC Stemness Regulation and the Contribution of CSCs to Cancer Hallmarks.

Figure 1.

CSC stemness is regulated by several key signaling pathways, including STAT3, SHH, NOTCH, PI3K, WNT/β-catenin, and NANOG. CSCs promote tumorigenesis and progression by contributing to at least nine out ten hallmarks of cancer. Whether CSCs contribute to the tenth hallmark of cancer, evading growth suppressors, remains unknown.