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. Author manuscript; available in PMC: 2021 Jan 27.
Published in final edited form as: Cell Rep. 2021 Jan 5;34(1):108597. doi: 10.1016/j.celrep.2020.108597

Figure 3. CSC Niche Components and the Role of Macrophages in CSC Stemness Maintenance.

Figure 3.

CSC niches are composed of several types of cells (including macrophages, tumor cells, mesenchymal stem cells, fibroblasts, and endothelial cells) and their cytokine/growth factor networks, ECM components, and hypoxic environment. Macrophages represent one of these niches, which promote CSC stemness through producing a large number of soluble factors as indicated.