Figure 2.

Schematic of various physical cues a biomaterial can present to the nearby cells and their effects on tissue regeneration. Overall pore architecture drives cell migration throughout the scaffold by providing ample nutrient and waste transport while providing surface area for cell attachment and growth. The attachment of cells is further enhanced by specific surface textures that aid attachment of specific cells and help guide cell growth and differentiation. The differentiation of attached cells can also be improved by tailoring the surface stiffness of the biomaterial to match that of the native tissue.