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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Curr Opin Biomed Eng. 2020 Dec 25;17:100260. doi: 10.1016/j.cobme.2020.100260

Figure 3.

Figure 3.

Graphical representation of biomaterial surface chemistry and associated cellular interactions. The wettability and polarity of the biomaterial surface guides attachment of serum proteins which then can aid or hinder the attachment of inflammatory cells that can help dictate whether the biomaterial will be targeted for inflammation or cell recruitment for tissue regeneration. Specific functional groups that are present on the surface can also help guide tissue regeneration by aiding/preventing inflammation. The surface of the biomaterial can be further functionalized for more specific tissue types by presenting inorganic factors like calcium apatites (Cap), ECM proteins, and/or growth factors (GF) to guide cell migration, growth, and differentiation.