TABLE 2.

Genomic loci associated with metabolites and metabolite ratios at genome‐wide significance in meta‐analysis

Locus	rsID	Metabolite/ratio a	Annotation b	Ref c	N	EA/OA d	Beta (SE e )	p f
LINC02267	rs117445861	Hypoxanthine	RINT	NAS	1551	A/G	−0.54 (0.08)	5.9E‐11
RHPN1	rs73365860	L‐Histidine/uric acid	DS	NL	1513	T/C	−0.17 (0.02)	3.3E‐12
FADS1	rs174548	cis‐5,8,11,14,17‐Eicosapentaenoic acid (C20:5n3)/LysoPC 20:2	INT	NAS	1551	C/G	−0.12 (0.02)	1.3E‐12
ZBTB16	rs573195	Inosine	INT	NL	1499	T/G	−0.52 (0.08)	1.2E‐11
ACADS	rs9204	2‐Methylsuccinic acid	UTR3	NAS	1551	A/G	0.37 (0.04)	3.4E‐20
LOC112268121	rs9530695	Eudesmic acid	IG	NL	1506	C/G	2.50 (0.32)	6.1E‐15
ERH	rs76199614	Glycochenodeoxycholic acid	DS	NAS	1515	A/G	0.29 (0.04)	1.2E‐10
SLC10A1	rs2296651	Glycocholic acid	MV	NL	1551	A/G	−1.31 (0.08)	4.2E‐63
GABRG3	rs58275387	Dodecanedioic aicd	INT	NL	1542	T/C	−0.34 (0.05)	2.6E‐10
ACSM5	rs9929808	3‐Indolepropionic acid	INT	NAS	1551	T/C	−0.77 (0.07)	2.1E‐32
	rs6497488	3‐Indolepropionic acid	INT	NAS	1500	T/C	−0.40 (0.06)	5.6E‐11
ACSM2B	rs11645661	3‐Indolepropionic acid	UTR3	NL	1548	A/G	−0.69 (0.07)	3.7E‐22
TBX4	rs8073361	Eudesmic acid	IG	NAS	1551	A/C	−1.97 (0.30)	8.8E‐11
PWP2	rs74716564	1,4‐dihydro‐1‐Methyl‐4‐oxo‐3‐pyridinecarboxamide	INT	NL	1525	A/G	−0.47 (0.07)	6.4E‐11

^aThe “/” represents a ratio relationship, the front is the numerator, the back is the denominator.

^bSNP annotation, UTR3 (3′ Untranslated Region), DS (downstream), IG (intergenic), INT (Intronic), MV (Missense Variant), RINT (ncRNA_intronic).

^cNovel Locus (NL) or Novel Association (NAS).

^dEffect/other allele.

^eStandard error.

^fMeta‐analysis p‐value.