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. 2021 Jan 14;17(1):e1009183. doi: 10.1371/journal.ppat.1009183

Fig 4. Sensitivities of tested PKRs projected on a PKR phylogenetic tree.

Fig 4

A maximum-likelihood phylogenetic tree of PKR from selected mammalian species including the ones tested in this study was generated. The tree was rooted to Tasmanian devil PKR. Bootstrap values ≥ 50 are indicated on the branches. Relative sensitivities of PKRs to VACV K3, VARV C3, CPXV-D 043/TATV 037, or CMLV 032 obtained from multiple experiments with PKR:K3 ortholog ratios of 1:1 and 1:2 are shown on a scale from 1 to 6: 1 = no or very weak inhibition (≤ 2 fold); 2 = weak inhibition (2 to 3-fold); 3 = intermediate low inhibition (3 to 5-fold); 4 = intermediate high inhibition (5 to 7 fold); 5 = high inhibition (7 to 10-fold); 6 = very high inhibition (≥ 10-fold).