Table 1. Summary of species-specific inhibition of PKR by K3 orthologs.
| Virus | Inhibition of Host PKR | Inhibition of mouse PKR | Inhibition of human PKR | Citations |
|---|---|---|---|---|
| Vaccinia | unknown | strong | weak | [8,9,17]; this paper |
| Variola | weak | intermediate | weak | this paper |
| Camelpox | strong | strong | strong | this paper |
| Cowpox D-clade | unknown | strong | strong | this paper |
| Myxoma | strong | weak | weak | [18] |
| Sheeppox | strong | weak | strong | [17] |
| Goatpox | strong | weak | strong | [17] |
| Lumpy skin disease | weak | weak | strong | [17] |
| Swinepox | strong | weak | weak | [31]* |
| Yaba monkey tumor | strong | weak | strong | [31]* |
* This study inferred species-specific PKR inhibition by correlation of replication and eIF2a phosphorylation mediated by VACV expressing different K3 orthologs. It did not characterize inhibition of PKR by K3 orthologs directly.