Table 3.
Bacteria Discriminative for Gastrointestinal Infection Groups as Identified by metagenomeSeq and Random Forest
| Operational Taxonomic Unit | Log Fold Change | P Value | Adjusted P Value | Methoda |
|---|---|---|---|---|
| Associated with disease (GII) | ||||
| Klebsiella (7) | −7.20 | <.0001 | <.0001 | Both |
| Leuconostoc (9) | −4.20 | <.0001 | <.0001 | MGS |
| Lactobacillus algidus (34) | −3.36 | <.0001 | <.0001 | MGS |
| Vagococcus (13) | −3.33 | <.0001 | <.0001 | MGS |
| Staphylococcaceae (101) | −2.81 | <.0001 | <.0001 | MGS |
| Pedobacter (30) | −2.32 | <.0001 | .0001 | MGS |
| Thermus thermophilus (26) | −2.00 | .0017 | .0096 | MGS |
| Anoxybacillus (33) | −1.88 | <.0001 | <.0001 | MGS |
| Shewanella (69) | −1.58 | <.0001 | <.0001 | MGS |
| Flavobacterium (14) | −1.23 | .0065 | .0235 | MGS |
| Vagococcus (20) | −1.21 | .0052 | .0206 | MGS |
| Myroides (38) | −1.14 | .0013 | .0080 | MGS |
| Associated with health (absence of GII) | ||||
| Acinetobacter (10) | 5.06 | <.0001 | <.0001 | MGS |
| Aerococcus (42) | 3.68 | <.0001 | <.0001 | MGS |
| Acinetobacter (47) | 3.14 | <.0001 | <.0001 | MGS |
| Acinetobacter soli (41) | 2.34 | <.0001 | <.0001 | MGS |
| Wautersiella (61) | 2.15 | <.0001 | <.0001 | MGS |
| Moraxella (1) | 1.77 | .0120 | .0409 | MGS |
| Haemophilus (4) | 1.72 | .0172 | .0513 | MGS |
| Corynebacterium propinquum (2) | 1.71 | .0165 | .0502 | MGS |
| Bergeyella (50) | 1.61 | .0035 | .0164 | MGS |
| Psychrobacter (8) | 1.52 | .0333 | .0858 | MGS |
| Cloacibacterium (94) | 1.48 | <.0001 | .0000 | MGS |
| Helcococcus (22) | 1.48 | .0234 | .0634 | MGS |
| Schlegelella (40) | 1.45 | .0003 | .0023 | MGS |
| BD1 5 (35) | 1.39 | .0232 | .0634 | MGS |
| Actinobacillus porcinus (37) | 1.39 | .0051 | .0206 | MGS |
| Moraxella (59) | 1.29 | .0059 | .0220 | MGS |
| Lysobacter (103) | 1.23 | .0002 | .0015 | MGS |
| Stenotrophomonas maltophilia (58) | 1.19 | .0307 | .0808 | MGS |
| Rothia (32) | 1.16 | .0053 | .0206 | MGS |
| Veillonella (70) | 1.05 | <.0001 | .0003 | MGS |
| Alloprevotella (54) | 1.05 | .0053 | .0206 | MGS |
| Veillonella (62) | 1.03 | .0014 | .0082 | MGS |
| Moraxella (60) | 1.00 | .0162 | .0502 | MGS |
P values have been adjusted using Benjamini-Hochberg correction for multiple testing.
Abbreviations: GII, gastrointestinal infection; MGS, metagenomeSeq.
aBoth methods adjusted for age.