Table 1.

Top 15 PheWAS ICD9 phenotypes for PNPLA3 rs738409 (adjusted for age, sex and principle components).

ICD-9	Beta	Standard error	Odds ratio	p value	Description	Organ system
571.8	0.0160	0.0019	1.66	1.91E-17	Other chronic non-alcoholic liver disease	Digestive
572.3	0.0084	0.0014	1.65	7.43E-10	Portal hypertension	Digestive
456.1	0.0072	0.0012	1.69	7.18E-09	Esophageal varices without mention of bleeding	Digestive
571.5	0.0125	0.0022	1.34	1.10E-08	Cirrhosis of liver without mention of alcohol	Digestive
456.21	0.0063	0.0012	1.61	2.34E-07	Esophageal varices, without bleeding, elsewhere	Digestive
571.2	0.0050	0.0010	1.91	3.10E-07	Alcoholic cirrhosis of liver	Mental disorders
572.8	0.0048	0.0010	1.58	2.52E-06	Other sequelae of chronic liver disease	Digestive
456.8	0.0033	0.0007	1.90	7.26E-06	Varices of other sites	Circulatory system
789.59	0.0061	0.0014	1.37	1.11E-05	Other ascites	Digestive
303.9	0.0056	0.0014	1.30	4.12E-05	Alcohol dependence, unspecified drinking behavior	Mental disorders
573.8	0.0048	0.0012	1.30	5.91E-05	Other specified disorders of liver	Digestive
456.2	0.0026	0.0007	1.88	0.00017	Esophageal, with bleeding	Digestive
537.89	0.0068	0.0018	1.29	0.00017	Other specified disorders of stomach and duodenum	Digestive
369.69	0.0007	0.0002	3.15	0.00024	One eye: profound vision impairment; other eye: normal vision	Sense organs
141.90	0.0012	0.0003	2.73	0.00031	Malignant neoplasm of tongue, unspecified	Neoplasms
571.1	0.0019	0.0005	1.89	0.00037	Acute alcoholic hepatitis	Mental disorders
794.80	0.0050	0.0014	1.32	0.00039	Non-specific abnormal results of function study of liver	Digestive
572.4	0.0020	0.0006	1.74	0.00043	Hepatorenal syndrome	Digestive
790.6	0.0097	0.0028	1.13	0.00050	Other abnormal blood chemistry	Symptoms

Shaded cells represent phenome-wide significant hits (p <6.37 × 10 ⁻⁶). Naïve odds ratios, for the impact of PNPLA3 rs738409 “G”, are based on case:control counts. PheWAS, phenome-wide association study.