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. 2020 Sep 23;7(5):ENEURO.0376-19.2020. doi: 10.1523/ENEURO.0376-19.2020

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Copyright © 2020 Driscoll et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — N/OFQ effects in VTA neurons vary with projection target. A, For each retrograde tracer injection site, example histology photograph showing DiI localization (left) and mirrored, modified rat brain atlas schematic (right; Paxinos and Watson, 1997). B, Cartoon showing the experimental approach: 7 d before recording, the retrograde tracer DiI was stereotaxically injected into mPFC, pACC, or medial NAc. DiI neurons were identified during whole-cell recordings (inset). C, Example image of a neuron filled with biocytin during recording (green), the retrograde tracer (red), and was immunocytochemically identified as TH(+) (turquoise). D, The overall percentage of neurons that responded to N/OFQ was greatest among pACC-projecting neurons and lowest among NAc-projecting neurons. E, Graph of magnitudes of significant N/OFQ responses, showing that only pACC-projecting neurons respond to N/OFQ with an inward current.