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. 2021 Jan 4;10:e65282. doi: 10.7554/eLife.65282

Figure 5. Model of RhopH synthesis and trafficking.

Figure 5.

The complex is produced in a soluble form and packaged into rhoptries (1) before transfer via extracellular merozoites to the nascent parasitophorous vacuole of a new host erythrocyte (2). The rhoptry may also contribute lipids to the nascent parasitophorous vacuole (Dluzewski et al., 1995). The soluble RhopH complex then crosses the PVM and undergoes membrane insertion via a PTEX-dependent mechanism (3). Finally, it is deposited on the host membrane with a small variant region on CLAG3 exposed to plasma, enabling channel-mediated nutrient uptake (4).