Fig. 3. Central gain enhancement. A: Intact cochlear input. An intact cochlea modulates the activity of the corresponding auditory cortex. B: Damaged cochlear input. A cochlear lesion (C6) alters inhibitory synapses in the corresponding auditory cortex area (AC6), which in turn increases spontaneous activity that results in tinnitus. This occurs in a frequency-dependent manner modulated by amygdala. AC: auditory cortex, C: cochlea.
