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. 2020 Dec 15;120(2):352–369. doi: 10.1016/j.bpj.2020.12.001

Figure 3.

Figure 3

Examples of PVC behaviors in 1D cables. Upper panel: APs from an isolated single cell with the parameters in the long APD region (magenta) and the short APD region (black). Lower panel: 3D plots of time-space-voltage from the 1D cable. Magenta is the long APD region, and black is the short APD region. (A–C) The LRd model is shown. The symbols above the panels correspond to those marked on the middle panel in Fig. 2A (the LQT2 case of the LRd model) to indicate their locations in the phase diagram. Diamond (A): α(PCa) = 3 and α(GKs) = 0.1. Triangle (B): α(PCa) = 3 and α(GKs) = 0.3. The long AP in the single cell repolarizes at t = 3.55 s (see inset). Square (C): α(PCa) = 2.4 and α(GKs) = 0.905. (D–F) ORd model is shown. The symbols above the panels correspond to those marked on the middle panel in Fig. 2F (the LQT2 case of the ORd model) to indicate their locations in the parameter space. Circle (D): α(PCa) = 10 and α(GKs) = 1. Star (E): α(PCa) = 6 and α(GKs) = 1. The long AP in the single cell fails to repolarize for the entire duration of simulation (see inset). Pentagon (F): α(PCa) = 2.5 and α(GKs) = 5. To see this figure in color, go online.