Figure 1.

Possible consequences of membrane-bound disordered protein interacting with ligand. (A) A cartoon of the T cell receptor complex is given. (Bi) Interaction of ligand (orange circle) with membrane-bound disordered protein with multiple binding sites (black stars) is shown, where (Bii) binding causes local stiffening near posttranslational modification (e.g., phosphorylation; red stars), (Biii) phosphorylation reduces membrane association of the polymer, or (Biv) the ligand remains bound while more ligands attempt to bind simultaneously. (C) A snapshot of the residue-scale computational model of T cell receptor is given. To see this figure in color, go online.