Figure 2.

Binding rate differences imply emergent preference of (de)phosphorylation sequence. Probability of (A) phosphorylating or (B) dephosphorylating membrane proximal to distal (123456) compared with membrane distal to proximal (654321) is shown. Each of these is shown for (i) with a membrane, assuming sites spaced like tyrosines of ζ; (ii) without a membrane, assuming sites spaced like tyrosines of ζ; and (iii) without a membrane, assuming sites spaced evenly. Black dotted lines indicate the probability if all events were equally likely (1/6! = 1/720). Error bars (A and B) represent standard error of the mean. To see this figure in color, go online.