Skip to main content
. 2020 Dec 19;120(2):306–318. doi: 10.1016/j.bpj.2020.12.007

Figure 4.

Figure 4

Superimpositions of protein motion at the main normal mode with the lowest-frequency motion in stereo pair view for the wild-type and mutant GTP-bound (left column) and wild-type and mutant GDP-bound (right column) Cdc42. The images show the full range of motion for each residue. The motion clearly shows the loss of insert region integrity in the GDP-bound systems and the conformational flexibility of the switch I and switch II regions. Although the insert region has a visible range of motion in the GTP-bound wild-type and G12V mutant, it still maintains its helical structure.