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The potential of mean force (ΔGPMF) along the reaction coordinates d1 (defined by the distance from G60-Cα to GTP/GDP-Pβ atom) and d2 (defined by the distance from T35-Cα to GTP/GDP-Pβ). As seen, the distances are very stable in the GTP-bound systems and the GDP-bound Q61L mutant. Both d1 and d2 fluctuate more in the GDP-bound G12V mutant, and they fluctuate to a lesser extent in the GDP-bound wild type. To see this figure in color, go online.
