Table 1. ISMs selected using HE procedure described in the present study and 20 ISMs signature captured by Zhao et al. (2020) .

	90 K database–HE algorithm							90 K database – Zhao et al. (2020) ISMs signature
	All database		Before 18 June 2020		After 17 June 2020			All database		Before 18 June 2020		After 17 June 2020
Sites common in all columns are in bold. Database used by Zhao et al. (2020) was downloaded on 17 June 2020; table shows values obtained according to this timepoint. Asterisks indicate ISMs retained in 11 ISMs set by Zhao et al. (2020) out of the 20 initially selected by their algorithm; HE algorithm prioritizes other ISMs not included by Zhao et al. among the 20 top candidates, which instead includes several that are not considered among the top 20 prioritized by the HE algorithm.
	Site	HE	Site	HE	Site	HE		Site	HE	Site	HE	Site	HE
#1	28881	0.93	241	0.86	28881	0.99		28881*	0.93	241	0.86	28881*	0.99
#2	25563	1.58	25563	1.58	25563	1.58		25563*	1.58	25563*	1.58	25563*	1.58
#3	241	2.06	28881	2.07	241	1.97		241	2.06	28881*	2.07	241	1.97
#4	11083	2.37	11083	2.41	1163	2.35		11083*	2.37	11083*	2.41	11083*	2.24
#5	1163	2.61	1059	2.64	11083	2.61		1059*	2.59	1059*	2.64	1059*	2.45
#6	1059	2.83	8782	2.84	28854	2.83		20268*	2.78	8782*	2.84	20268*	2.64
#7	20268	3.02	20268	3.03	1059	3.03		14805*	2.93	20268*	3.03	14805*	2.75
#8	14805	3.17	14805	3.21	19839	3.21		8782*	3.06	14805*	3.21	8782*	2.82
#9	23731	3.31	15324	3.33	23731	3.37		18060*	3.12	17747	3.30	14408	2.87
#10	28854	3.45	27964	3.44	20268	3.52		14408	3.18	2558*	3.36	18060*	2.92
#11	19839	3.58	10097	3.54	27964	3.65		2558*	3.22	3037	3.42	23403*	2.95
#12	8782	3.70	28854	3.64	313	3.77		23403*	3.25	26144*	3.45	2558*	2.99
#13	27964	3.83	27046	3.73	14805	3.88		3037	3.28	14408	3.48	3037	3.01
#14	15324	3.93	17747	3.81	11916	3.98		26144*	3.31	28144	3.50	17747	3.03
#15	313	4.03	25429	3.89	15324	4.07		17747	3.32	18060*	3.52	26144*	3.04
#16	11916	4.12	11916	3.97	22480	4.15		28144	3.33	23403*	3.54	28882	3.05
#17	18877	4.19	313	4.04	8782	4.22		28882	3.34	2480	3.54	2480	3.05
#18	25429	4.26	29553	4.11	21575	4.29		2480	3.35	28882	3.55	28144	3.05
#19	18060	4.32	19839	4.18	18877	4.35		17858	3.35	17858	3.55	17858	3.06
#20	21575	4.38	18877	4.24	13862	4.41		28883	3.35	28883	3.56	28883	3.06