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. 2021 Jan 14;11:624429. doi: 10.3389/fphar.2020.624429

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Copyright © 2021 Liu, Tang, Ji, Gu, Chen, Huang, Zhao, Sun, Wang, Guan, Liu and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hippocampal infusion of ARN-3236 protected against the decreasing effects of chronic stress on the hippocampal BDNF system. (A) Representative western blotting images and quantitative analyses show the effects of CSDS and ARN-3236 on the expression of the hippocampal BDNF-TrkB-ERK1/2/AKT/CaMKIV-CREB pathway. (B) Representative western blotting images and quantitative analyses show the effects of CUMS and ARN-3236 on the level of the hippocampal BDNF-TrkB-ERK1/2/AKT/CaMKIV-CREB pathway. All results were represented as means ± S.E.M (n = 5); *p < 0.05, **p < 0.01. The comparisons were made by two-way ANOVA followed by Bonferroni's test.