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. 2021 Jan 14;11:624429. doi: 10.3389/fphar.2020.624429

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Copyright © 2021 Liu, Tang, Ji, Gu, Chen, Huang, Zhao, Sun, Wang, Guan, Liu and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hippocampal CRTC1-knockdown by using AAV-CRTC1-shRNA abolished the antidepressant-like effects of ARN-3236 in mice. (A) Schematic timeline of the CSDS-involved experimental procedures. (B–E) AAV-CRTC1-shRNA pre-infusion significantly prevented the reversal effects of ARN-3236 on the CSDS-induced depressive-like behaviors in the FST, TST, SPT and social interaction test. (F) Schematic timeline of the CUMS-involved experimental procedures. (G–I) AAV-CRTC1-shRNA pre-infusion fully blocked the restoring effects of ARN-3236 on the CUMS-induced depressive-like behaviors in the FST, TST and SPT. All results were represented as means ± S.E.M (n = 10); **p < 0.01; n.s., no significance. The comparisons were made by one-way ANOVA followed by Tukey's test.