Table 1.

Pediatric healthcare institutions with PGx implementation projects.

Healthcare institution	Genes implemented	Associated drugs
St. Jude Children’s Research Hospitala	TPMT/NUDT15	Thiopurines
	CYP2C9	Celecoxib
	CYP2C19	Clopidogrel, amitriptyline, clomipramine, imipramine, trimipramine, doxepin, voriconazole, PPIs
	CYP2D6	Codeine, oxycodone, tramadol, amitriptyline, clomipramine, imipramine, trimipramine, doxepin, fluoxetine, paroxetine, ondansetron,
	CYP3A5	Tacrolimus
	DPYD	Fluoropyrimidines
	SLCO1B1	Simvastatin
	UGT1A1	Atazanavir
	mt-RNR1	Aminoglycoside antibiotics
	RYR1/CACNA1S	Succinylcholine and volatile fluorinated anesthetics
Children’s Minnesotab	TPMT/NUDT15	Thiopurines
	CYP2C9	Phenytoin, fosphenytoin
	CYP2C19	Citalopram, escitalopram, amitriptyline, clomipramine, imipramine, trimipramine, doxepin, voriconazole
	CYP2D6	Atomoxetine, aripiprazole, amitriptyline, clomipramine, imipramine, trimipramine, doxepin, desipramine, nortriptyline, paroxetine, fluvoxamine, ondansetron, tramadol
	CYP3A5	Tacrolimus
	DPYD	5-Fluorouracil
	RYR1/CACNA1S	Succinylcholine and volatile fluorinated anesthetics
University of Florida in partnership with Nemours Children’s Specialty Care, Jacksonville, FL and Nemours Children’s Hospital, Orlando, FLc	TPMT/NUDT15	Thiopurines
	CYP2C19	PPIs
Boston Children’s Hospitald	TPMT/NUDT15	Thiopurines
	CYP2C9	Phenytoin, fosphenytoin, glimepiride, glipizide, glipizide-metformin, glyburide, glyburide-metformin, glimepiride-pioglitazone, glimepiride-rosiglitazone, irbesartan, hydrochlorothiazide-irbesartan, losartan, hydrochlorothiazide-losartan, tolbutamide, warfarin
	CYP2C19	Amitriptyline, amitriptyline/chlordiazepoxide, amitriptyline/perphenazine, citalopram, clobazam, clomipramine, clopidogrel, doxepin, escitalopram, esomeprazole, esomeprazole/naproxen, imipramine, lansoprazole, lansoprazole/amoxicillin/clarithromycin, lansoprazole/naproxen, omeprazole, omeprazole/sodium bicarbonate, omeprazole/clarithromycin/amoxicillin, pantoprazole, rabeprazole, sertraline, voriconazole
	VKORC1	Warfarin
	HLA-A	Carbamazepine
	HLA-B	Abacavir, allopurinol, carbamazepine, fosphenytoin, oxcarbazepine, phenytoin
Cincinnati Children’s Hospital Medical Centere	TPMT/NUDT15	Thiopurines
	CYP2C19	Amitriptyline, clomipramine, imipramine, trimipramine, doxepin, clopidogrel, voriconazole, PPIs
	CYP2D6	Codeine, hydrocodone, oxycodone, tramadol, aripiprazole, haloperidol, olanzapine, perphenazine, risperidone, thioridazine, amitriptyline, clomipramine, imipramine, trimipramine, doxepin, desipramine, maprotiline, nortriptyline, fluoxetine, paroxetine, fluvoxamine, venlafaxine

^aHaidar et al. [15].

^bUnpublished data, courtesy of D Gregornik, PharmD, Children’s Minnesota.

^cWeitzel et al. [19] and Cicali et al. [20].

^dManzi et al. [13] and Kim et al. [46].

^eRamsey et al. [21], https://www.cincinnatichildrens.org/service/g/genetic-pharmacology/education, accessed 20 Nov 2019.