Fig. 3.

Mapping of overlapping peptides from recombinant cathepsin L1 peptide arrays which were recognised by host antibodies from sheep (A) and cattle (B) experimentally infected with Fasciola hepatica. The putative linear epitope is highlighted in red. Epitopes recognised by experimentally infected sheep (highlighted in red [epitope 1], purple [epitope 2], dark blue [epitope 3] and light blue [epitope 4]) were mapped onto a 3D surface model the mature CL1 protein (Stack et al., 2007) shown in (C), are located away from the active site (in green). An alternative view (rotated 180°) is shown in (D).