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. 2021 Jan 14;11:609689. doi: 10.3389/fimmu.2020.609689

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Copyright © 2021 Kim, Yi, Kim, Lee, Chung, Ha, Cho, Kim, Ko, Cheon, Hong and Chang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CG-598 mitigates DNBS-induced colitis in a dose-dependent manner. Mice were administered intra-rectally with 3% DNBS (n=9 or 10 per group). Three different doses of CG-598 or vehicle formulation were orally administered once a day. (A) Body weights. Two-way ANOVA. ***p < 0.001, compared to the vehicle group. (B) Colon lengths at day 4. One-way ANOVA. ns; not significant, *p < 0.05, **p < 0.01. (C) Representative colon histology from each group (×200 magnification). Black arrows mark severely inflamed regions. (D) Histological score. Data are representative of three independent experiments. One-way ANOVA. Data are shown as mean ± SEM, ns, not significant.