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. 2021 Jan 14;11:609689. doi: 10.3389/fimmu.2020.609689

Figure 4.

Figure 4

CG-598 reduces the severity of DSS-induced colitis. Mice were fed with 2.5% DSS in drinking water for five days and changed to normal water afterwards (n=9 per group). Mice were treated with CG-598 or AKB-4924 by oral gavage once every day. (A) Body weights. Two-way ANOVA. (B) Colon length at day 11. (C) Disease activity index. Two-way ANOVA. (D) Representative H&E stained colon tissues at day 11 (×200 magnification) and (E) Histological score. (F) Bacterial CFU counts in MLNs and (G) spleens isolated at day 11. (H) Levels of TNF-α, IL-1β, IFN-γ and (I) IL-10 were analyzed from colon tissue homogenates at day 11. Data are representative of three independent experiments. One-way ANOVA. Data are shown as mean ± SEM, (A–C) compared to vehicle group. (E–I) ns; not significant, *p < 0.05, **p < 0.01, ***p < 0.001 compared to healthy control group, #p < 0.05, ##p < 0.01, ###p < 0.001 compared to vehicle group.