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. 2021 Jan 14;11:603830. doi: 10.3389/fphar.2020.603830

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Copyright © 2021 Liang, Qiu, Niu, Ma, Zhou, Chen, Zhang, Chen, Yang, Liu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The interaction of HP-OVA with SARS-CoV-2 S and ACE2. The binding of OVA to SARS-CoV-2 spike (RBD), S2 and BSA protein was assessed by ELISA (A). The binding of HP-OVA to SARS-CoV-2 spike (RBD), S2 and a negative control BSA protein was assessed by ELISA (B). The binding ability of HP-OVA to ACE2 protein was assessed by ELISA (C). Inhibition of the interaction between spike (RBD) and ACE2 proteins by HP-OVA, as determined by a competitive inhibition ELISA (D). Data are presented as the mean ± SD of triplicate samples from a representative experiment (*p < 0.05, **p < 0.01, ***p < 0.001).