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. 2021 Jan 14;11:614313. doi: 10.3389/fmicb.2020.614313

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Copyright © 2021 Strong and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mycobacterium tuberculosis inhibits autophagy to enhance survival in host cells. (A) While autophagy can be explained in terms of its role in cell survival, the mechanism by which it is regulated is complicated and elaborate. The different steps of the autophagic pathway during mycobacterial infection are shown. (B) Mtb-autophagy interaction in macrophages. Following phagocytosis, Mtb resides in phagosome and blocks phagosome maturation. Mtb secretes Esx-1, promoting phagosome damages that trigger ubiquitination, recruitment of autophagic adaptors and mycobacterial capture via STING. The detailed molecular mechanisms of each steps and mycobacterial factors are discussed in the text.