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. 2021 Jan 14;11:576743. doi: 10.3389/fimmu.2020.576743

Figure 6.

Figure 6

Lymphocyte Activation Gene 3 (LAG-3)-mediated enhancement of anti-parasite immunity is not dependent on CD8+ T cells. PD-L1-/- mice were injected i.p. with PBS or 150µg of either anti-CD4 or anti-CD8β depleting mAbs as depicted and inoculated with 2x105 Py 17XNL1.1 iRBC i.v. Mice also received either 300 µg anti-LAG-3 or isotype Ab i.v. on day 9, 12, and 15 post Py infection. Results show blood parasitemia measured by YOYO-1 staining of RBC, and change in initial weight (lower panel) over time starting on day 4 post Py infection. Anti-CD8β + isotype (n=3), anti-CD4 + isotype (n=7), Anti-CD8β + anti-LAG3 (n=5), anti-CD4 + anti-LAG3 (n=8), isotype (n=4), anti-LAG3 (n=5). Graphs are representative of two independent experiments (n=3–4) shown with SEM. Student t-test was conducted between each treatment compared to isotype (asterisk color indicate respective group), p-values are indicated when applicable (*p < 0.05).