Table 2.

Survival analysis and function of the 38 genes determined to be part of the final gene signature (38-OG) and their functions

Gene	Q4_HR (95% CI)	Q4_p	*RRS in 38	Function
UBE2J1	0.63 (0.40-0.99)	4.37E-02	-0.091	Targets misfolded MHC class I proteins for degradation [21]
C1orf74	0.56 (0.35-0.88)	1.28E-02	-0.081	Unknown function
CLEC6A	0.45 (0.28-0.73)	1.33E-03	-0.081	Stimulate dendritic cells and T-cells [22,23]
BTLA	0.54 (0.34-0.87)	1.01E-02	-0.067	Dual role in prolonging T-cell survival but also can depress T-cell response [24,25]
XBP1	0.48 (0.3-0.77)	2.43E-03	-0.066	Promote Th2 expansion, and NK cell response [26,27]
TRIM27	0.62 (0.39-0.99)	4.29E-02	-0.065	Positive regulation of TNF-alpha induced apoptosis, interferon gamma production [28,29]
EIF4E3	0.53 (0.33-0.86)	1.03E-02	-0.062	Involved in the innate immune system pathway and interferon gamma signaling [30]
MON1A	0.52 (0.33-0.84)	7.57E-03	-0.060	Membrane trafficking via the secretory pathway not lysosomal route [31]
SOCS2	0.56 (0.35-0.9)	1.64E-02	-0.060	Important for T-helper cell type 1 function [32]
GMPPB	0.58 (0.36-0.92)	2.12E-02	-0.059	Catalyzes the formation of essential glycan precursors. Glycans are essential for immune function [31,33]
LRRC45	0.56 (0.35-0.9)	1.61E-02	-0.056	Part of centrosome construction [34]
LCK	0.70 (0.43-1.12)	1.36E-01	-0.055	Involved in selection and maturation of T cells [35]
UBB	0.56 (0.35-0.9)	1.62E-02	-0.055	Stimulate apoptosis through the mitochondrial pathway, tag proteins for degradation, DNA repair [30,36]
FBF1	0.53 (0.32-0.86)	9.62E-03	-0.054	Required for epithelial cell polarization and centrosome formation [37]
CLPTM1L	0.67 (0.42-1.07)	9.21E-02	-0.048	Involved in stimulating apoptosis in response to DNA damage [38]
MLLT4	1.18 (0.73-1.89)	5.05E-01	-0.048	Tumor suppressor function [39]
SHISA5	0.64 (0.4-1.02)	6.30E-02	-0.047	With p53 induces apoptosis in caspase dependent manner [40]
CYP2R1	0.71 (0.45-1.11)	1.31E-01	-0.045	Important for Vitamin D production, which is associated with natural killer cell function [41,42]
SPEN	1.50 (0.94-2.39)	9.11E-02	-0.037	Cell cycle regulation [43]
ME1	0.56 (0.35-0.91)	1.83E-02	-0.034	Role in bacterial response [44]
SOCS5	1.49 (0.93-2.38)	9.71E-02	0.035	Inhibit dendritic cell function [45]
EMP1	1.76 (1.11-2.81)	1.63E-02	0.037	Promotes proliferation and cell survival [46]
AGFG1	1.69 (1.08-2.64)	2.06E-02	0.053	circularRNA form promotes proliferation, metastasis, and increased cyclin expression E expression (known contributor to platinum resistance) [47-49]
METTL1	0.86 (0.53-1.38)	5.30E-01	0.055	Promotes cell proliferation and migration [50]
TSPAN9	1.65 (1.03-2.64)	3.62E-02	0.057	Promotes autophagy [51]
PYGM	1.7 (1.08-2.7)	2.33E-02	0.058	Increases glycogen usage especially in muscles that do not utilize oxygen [52]
VPS24	1.75 (1.11-2.77)	1.66E-02	0.061	Promotes autophagy [53]
PYGB	1.95 (1.23-3.09)	4.27E-03	0.062	Role in promoting growth under hypoxic conditions [54]
CCDC144C	2.08 (1.29-3.35)	2.48E-03	0.063	Psuedogene, expression has been associated with paclitaxel resistance [55]
ANGPT4	1.83 (1.15-2.94)	1.14E-02	0.078	Promote vascular growth and recruitment of fibroblasts [56]
WWP1	1.49 (0.93-2.4)	9.58E-02	0.078	Promote proliferation, involved in autophagy [57]
RPL23P8	1.72 (1.09-2.71)	2.07E-02	0.079	Ribosomal Function Protein (Psuedogene) [30]
PEX3	1.87 (1.13-3.09)	1.43E-02	0.083	Promotes autophagy [58]
SUSD5	2.09 (1.3-3.36)	2.22E-03	0.083	Promotes proliferation and metastasis [59]
STAC2	2.46 (1.5-4.04)	3.61E-04	0.088	Promotes cell membrane transport activity [31]
KIAA1033	1.66 (1.04-2.65)	3.33E-02	0.090	Role in promoting growth under hypoxic conditions [54]
PI3	1.52 (0.98-2.35)	6.06E-02	0.091	Involved in proliferation and survival [60]
CALML3	2.00 (1.27-3.17)	2.91E-03	0.105	Promotes cell proliferation metastasis [61]

*Q4 is the fourth quartile, HR hazard ratio, CI confidence interval;

^*RRS in 38 refers to the ridge regression coefficient for each gene as determined by the 68 best models.