Table 3.
Survival Analysis for 68 best Ridge regression models from the 38-gene signature
| Model# | Training and Testing | Entire Data Set | Bootstrapping (1000) | ||||||
|---|---|---|---|---|---|---|---|---|---|
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| Train HR (CI) | Train P | Test HR (CI) | Test P | HR (CI) | P-value | Mean HR (CI) | P < 1E-6* | P < 1E-10* | |
| 48 | 5.37 (3.18-9.09) | 3.74E-10 | 5.23 (3.01-9.07) | 3.94E-09 | 5.13 (3.52-7.47) | 1.4E-17 | 4.44 (3.37-6.04) | 240 | 760 |
| 56 | 6.04 (3.4-10.7) | 8.69E-10 | 5.22 (2.91-9.35) | 2.74E-08 | 5.53 (3.72-8.21) | 2.55E-17 | 5.21 (3.93-6.94) | 19 | 981 |
| 70 | 5.27 (2.97-9.37) | 1.44E-08 | 5.16 (3.02-8.84) | 2.19E-09 | 5.03 (3.41-7.41) | 3.38E-16 | 4.91 (3.84-6.43) | 109 | 891 |
| 73 | 5.02 (2.89-8.72) | 1.07E-08 | 5.05 (2.9-8.78) | 1.03E-08 | 5 (3.39-7.38) | 5.66E-16 | 5.2 (4.02-6.69) | 37 | 963 |
| 81 | 5.25 (2.99-9.24) | 8.29E-09 | 6.46 (3.62-11.5) | 2.75E-10 | 5.71 (3.83-8.52) | 1.28E-17 | 5.76 (4.31-7.65) | 4 | 996 |
| 129 | 5.61 (3.39-9.29) | 2.09E-11 | 5.66 (3.08-10.4) | 2.40E-08 | 5.56 (3.78-8.19) | 3.27E-18 | 5.3 (4.06-6.95) | 27 | 973 |
| 166 | 5.27 (2.98-9.31) | 1.13E-08 | 5.93 (3.44-10.2) | 1.44E-10 | 5.27 (3.59-7.76) | 2.76E-17 | 4.94 (3.76-6.79) | 67 | 933 |
| 235 | 5.91 (3.26-10.7) | 5.25E-09 | 5.4 (2.94-9.95) | 5.99E-08 | 5.7 (3.72-8.73) | 1.31E-15 | 5.1 (3.77-6.75) | 84 | 916 |
| 281 | 5.34 (3.02-9.44) | 7.93E-09 | 5.06 (3-8.51) | 1.07E-09 | 4.93 (3.37-7.2) | 1.71E-16 | 4.77 (3.65-6.34) | 102 | 898 |
| 305 | 5.17 (3.01-8.9) | 2.91E-09 | 5 (2.94-8.51) | 2.87E-09 | 5.15 (3.53-7.51) | 2.13E-17 | 5.5 (4.28-7.18) | 6 | 994 |
| 429 | 6.23 (3.52-11) | 3.24E-10 | 5.07 (2.69-9.53) | 4.86E-07 | 5.24 (3.47-7.93) | 3.98E-15 | 4.79 (3.7-6.4) | 96 | 904 |
| 530 | 5.66 (3.15-10.2) | 6.84E-09 | 5.17 (3.07-8.73) | 7.35E-10 | 5.33 (3.63-7.84) | 1.71E-17 | 4.78 (3.69-6.24) | 149 | 851 |
| 550 | 6.53 (3.68-11.6) | 1.49E-10 | 5.4 (3.03-9.62) | 1.03E-08 | 6.03 (4.01-9.07) | 5.22E-18 | 5.53 (4.26-7.22) | 4 | 996 |
| 594 | 5.54 (3.2-9.6) | 9.81E-10 | 5.7 (3.24-10) | 1.62E-09 | 5.62 (3.79-8.32) | 7.47E-18 | 5.42 (3.84-7.22) | 45 | 955 |
| 596 | 6.7 (3.77-11.9) | 8.18E-11 | 5.04 (2.93-8.67) | 5.09E-09 | 5.73 (3.88-8.46) | 1.82E-18 | 5.49 (4.15-7.16) | 9 | 991 |
| 725 | 5.03 (2.89-8.74) | 9.88E-09 | 5.14 (2.79-9.49) | 1.64E-07 | 4.52 (3.07-6.65) | 1.93E-14 | 4.34 (3.43-5.45) | 228 | 772 |
| 744 | 5.34 (2.99-9.54) | 1.49E-08 | 5.1 (2.9-8.96) | 1.59E-08 | 5.21 (3.49-7.8) | 9.05E-16 | 5.11 (3.97-6.56) | 30 | 970 |
| 833 | 6.38 (3.6-11.3) | 2.00E-10 | 5.1 (2.87-9.05) | 2.68E-08 | 5.69 (3.81-8.49) | 2.14E-17 | 5.44 (4.23-6.98) | 8 | 992 |
| 844 | 5.79 (3.34-10.1) | 4.31E-10 | 5.38 (3.04-9.53) | 7.77E-09 | 5.55 (3.74-8.24) | 1.76E-17 | 5.49 (4.3-7.16) | 8 | 992 |
| 899 | 5.04 (2.94-8.65) | 4.35E-09 | 5.99 (3.3-10.9) | 3.99E-09 | 5.3 (3.57-7.87) | 1.11E-16 | 5.21 (4.06-6.63) | 13 | 987 |
| 923 | 5.83 (3.28-10.4) | 1.87E-09 | 5.91 (3.28-10.6) | 3.22E-09 | 5.48 (3.69-8.14) | 2.98E-17 | 5 (3.87-6.69) | 43 | 957 |
| 924 | 5.23 (2.99-9.13) | 6.07E-09 | 6.86 (3.81-12.3) | 1.26E-10 | 5.78 (3.88-8.62) | 6.47E-18 | 5.66 (4.16-7.65) | 13 | 987 |
| 1005 | 5.25 (3.07-9) | 1.52E-09 | 5.11 (2.95-8.86) | 6.37E-09 | 4.95 (3.41-7.19) | 3.98E-17 | 4.61 (3.53-6.38) | 148 | 852 |
| 1042 | 5.35 (3.06-9.33) | 3.71E-09 | 5.17 (2.94-9.07) | 1.05E-08 | 5.3 (3.57-7.87) | 1.54E-16 | 5.23 (3.97-6.78) | 33 | 967 |
| 1046 | 5.04 (2.91-8.72) | 7.64E-09 | 5.56 (3.19-9.69) | 1.46E-09 | 5.03 (3.43-7.36) | 1.01E-16 | 5.14 (3.93-6.63) | 27 | 973 |
| 1079 | 5.12 (2.87-9.11) | 2.94E-08 | 5.1 (2.98-8.75) | 3.03E-09 | 4.84 (3.27-7.15) | 2.46E-15 | 4.87 (3.85-6.31) | 74 | 926 |
| 1128 | 5.31 (3.09-9.13) | 1.53E-09 | 5.3 (2.98-9.45) | 1.46E-08 | 5.47 (3.68-8.12) | 4.06E-17 | 5.34 (4.06-7) | 17 | 983 |
| 1176 | 6.9 (3.87-12.3) | 5.85E-11 | 5 (2.95-8.48) | 2.30E-09 | 5.54 (3.8-8.09) | 6.71E-19 | 4.71 (3.57-6.31) | 111 | 889 |
| 1253 | 6.21 (3.54-10.9) | 1.82E-10 | 5.29 (2.95-9.49) | 2.34E-08 | 5.66 (3.8-8.45) | 1.98E-17 | 5.18 (3.85-6.88) | 30 | 970 |
| 1293 | 5.16 (3-8.88) | 3.01E-09 | 5.21 (2.95-9.19) | 1.31E-08 | 5.11 (3.47-7.52) | 1.42E-16 | 4.64 (3.58-6.14) | 109 | 891 |
| 1352 | 5.68 (3.28-9.84) | 5.75E-10 | 5.56 (3.09-10) | 1.07E-08 | 5.71 (3.82-8.53) | 2.04E-17 | 5.52 (4.17-7.05) | 9 | 991 |
| 1506 | 5.29 (3.03-9.25) | 5.02E-09 | 6.13 (3.43-10.9) | 8.25E-10 | 5.15 (3.5-7.57) | 9.23E-17 | 4.78 (3.57-6.67) | 153 | 847 |
| 1561 | 6.39 (3.44-11.9) | 4.39E-09 | 5.6 (3.25-9.65) | 5.50E-10 | 5.97 (3.97-8.98) | 8.38E-18 | 5.8 (4.34-7.77) | 1 | 999 |
| 1569 | 5.3 (3.1-9.05) | 9.79E-10 | 5.68 (3.15-10.2) | 7.76E-09 | 5.41 (3.65-8.03) | 5.39E-17 | 5.18 (3.98-6.77) | 38 | 962 |
| 1589 | 5.2 (2.98-9.07) | 6.04E-09 | 6.09 (3.46-10.7) | 3.88E-10 | 5.55 (3.74-8.23) | 1.71E-17 | 5.27 (4.11-6.91) | 13 | 987 |
| 1623 | 10.9 (5.37-22.1) | 3.59E-11 | 5.18 (2.68-10) | 9.79E-07 | 6.26 (4.03-9.72) | 2.97E-16 | 5.55 (4.36-7.23) | 10 | 990 |
| 1639 | 5.11 (3.05-8.59) | 6.80E-10 | 6.14 (3.33-11.3) | 6.35E-09 | 5.59 (3.77-8.29) | 1.1E-17 | 5.41 (3.99-7.21) | 33 | 967 |
| 1657 | 5.29 (3.05-9.17) | 2.93E-09 | 5.51 (3.14-9.66) | 2.67E-09 | 5.28 (3.58-7.78) | 4.08E-17 | 5.29 (4.09-7.19) | 11 | 989 |
| 1684 | 5.49 (3.09-9.74) | 5.98E-09 | 5.21 (2.95-9.2) | 1.30E-08 | 4.83 (3.29-7.08) | 8.37E-16 | 4.85 (3.74-6.57) | 93 | 907 |
| 1701 | 5.19 (2.92-9.24) | 2.16E-08 | 5.4 (3.22-9.05) | 1.66E-10 | 4.98 (3.43-7.24) | 4.09E-17 | 5.96 (4.36-8.07) | 5 | 995 |
| 1719 | 5.77 (3.38-9.85) | 1.32E-10 | 5.07 (2.87-8.94) | 2.21E-08 | 5.44 (3.69-8.03) | 1.42E-17 | 5.35 (4.15-6.97) | 13 | 987 |
| 1758 | 5.49 (3.15-9.58) | 2.03E-09 | 5.43 (3.06-9.62) | 7.00E-09 | 5.51 (3.7-8.21) | 4.02E-17 | 5.37 (4.09-6.94) | 24 | 976 |
| 1818 | 5.49 (3.22-9.35) | 3.69E-10 | 5.58 (3.18-9.78) | 2.05E-09 | 5.51 (3.75-8.11) | 3.98E-18 | 5.27 (4.18-6.64) | 11 | 989 |
| 1822 | 5.18 (3.05-8.8) | 1.22E-09 | 6.08 (3.31-11.2) | 6.34E-09 | 5.46 (3.67-8.11) | 5.27E-17 | 4.99 (3.85-6.53) | 58 | 942 |
| 1864 | 6.22 (3.63-10.7) | 2.67E-11 | 5.59 (3.08-10.1) | 1.45E-08 | 5.44 (3.69-8.02) | 1.19E-17 | 5.44 (4.32-7.1) | 3 | 997 |
| 1878 | 5.74 (3.28-10) | 8.91E-10 | 5.35 (3.06-9.34) | 3.66E-09 | 5.53 (3.74-8.16) | 8.05E-18 | 5.31 (3.98-6.97) | 18 | 982 |
| 1999 | 5.04 (3-8.47) | 9.81E-10 | 5.07 (2.86-8.98) | 2.57E-08 | 4.98 (3.4-7.29) | 1.51E-16 | 4.83 (3.62-6.44) | 108 | 892 |
| 2064 | 6.92 (4.02-11.9) | 2.80E-12 | 5.39 (2.86-10.2) | 1.90E-07 | 5.92 (3.93-8.9) | 1.45E-17 | 5.78 (4.34-7.8) | 6 | 994 |
| 2065 | 6.68 (3.78-11.8) | 6.70E-11 | 5.08 (2.87-8.99) | 2.46E-08 | 5.63 (3.77-8.39) | 2.37E-17 | 5.37 (4.15-6.85) | 16 | 984 |
| 2066 | 5.54 (3.22-9.55) | 6.72E-10 | 5.85 (3.07-11.2) | 8.10E-08 | 5.41 (3.6-8.14) | 4.46E-16 | 5.28 (4.03-6.79) | 24 | 976 |
| 2090 | 5.27 (3.05-9.1) | 2.64E-09 | 5.35 (2.96-9.66) | 2.74E-08 | 5.31 (3.58-7.88) | 1.1E-16 | 5.25 (4.04-7.06) | 16 | 984 |
| 2125 | 5.68 (3.16-10.2) | 7.04E-09 | 5.56 (3.21-9.63) | 1.01E-09 | 4.98 (3.4-7.27) | 1.14E-16 | 4.97 (3.75-6.57) | 66 | 934 |
| 2136 | 5.13 (2.93-8.97) | 9.66E-09 | 5.13 (2.81-9.37) | 1.03E-07 | 4.98 (3.33-7.47) | 7.07E-15 | 4.93 (3.74-6.52) | 74 | 926 |
| 2206 | 6.6 (3.73-11.7) | 8.59E-11 | 5.18 (2.82-9.52) | 1.14E-07 | 5.02 (3.37-7.47) | 1.65E-15 | 4.8 (3.77-6.14) | 57 | 943 |
| 2267 | 5.44 (3.18-9.32) | 6.91E-10 | 5.42 (3.03-9.7) | 1.26E-08 | 4.84 (3.33-7.03) | 1.3E-16 | 4.66 (3.48-6.56) | 162 | 838 |
| 2278 | 5.32 (3.04-9.3) | 4.66E-09 | 5.32 (3.08-9.17) | 1.87E-09 | 5.36 (3.63-7.9) | 2.61E-17 | 5.26 (4.01-7.03) | 28 | 972 |
| 2298 | 5.19 (3.04-8.84) | 1.42E-09 | 5.1 (2.98-8.73) | 2.63E-09 | 4.95 (3.43-7.15) | 1.36E-17 | 5.09 (3.95-6.6) | 25 | 975 |
| 2342 | 5.06 (2.98-8.6) | 2.03E-09 | 5.12 (3.02-8.69) | 1.34E-09 | 5.01 (3.46-7.26) | 1.77E-17 | 4.79 (3.74-6.1) | 56 | 944 |
| 2346 | 5.31 (3.12-9.04) | 7.67E-10 | 5.01 (2.86-8.76) | 1.68E-08 | 5.21 (3.55-7.66) | 4.66E-17 | 5.06 (3.94-6.6) | 36 | 964 |
| 2423 | 5.05 (3.07-8.31) | 1.93E-10 | 5.05 (2.92-8.75) | 7.08E-09 | 4.9 (3.42-7.04) | 6.55E-18 | 5.26 (4.04-6.85) | 16 | 984 |
| 2509 | 5.17 (2.95-9.06) | 9.32E-09 | 5.31 (3.04-9.25) | 3.92E-09 | 5.14 (3.48-7.58) | 1.88E-16 | 5.31 (3.97-7.12) | 30 | 970 |
| 2553 | 5.4 (3.14-9.3) | 1.17E-09 | 5.26 (2.99-9.24) | 7.94E-09 | 5.32 (3.61-7.84) | 3.33E-17 | 5.56 (4.32-7.38) | 6 | 994 |
| 2576 | 7.49 (4.07-13.8) | 9.67E-11 | 6.61 (3.3-13.2) | 1.03E-07 | 5.79 (3.81-8.8) | 2.09E-16 | 4.63 (3.51-6.22) | 195 | 805 |
| 2635 | 5 (2.87-8.7) | 1.23E-08 | 5.84 (3.28-10.4) | 1.93E-09 | 5.3 (3.56-7.88) | 1.88E-16 | 5.05 (3.79-6.66) | 69 | 931 |
| 2764 | 5.12 (2.95-8.88) | 6.15E-09 | 5.07 (2.91-8.83) | 1.02E-08 | 5.19 (3.51-7.69) | 1.76E-16 | 5.37 (3.99-7.39) | 35 | 965 |
| 2868 | 5.11 (2.94-8.89) | 7.92E-09 | 5.16 (3.04-8.74) | 1.07E-09 | 5.02 (3.46-7.3) | 2.42E-17 | 5.14 (3.92-7.04) | 25 | 975 |
| 2869 | 5.45 (3.24-9.17) | 1.58E-10 | 5 (2.88-8.68) | 1.04E-08 | 4.93 (3.41-7.13) | 2.11E-17 | 5.06 (3.88-6.81) | 34 | 966 |
| 2954 | 5.36 (3.04-9.44) | 6.00E-09 | 6.53 (3.34-12.8) | 4.36E-08 | 5.98 (3.89-9.2) | 3.47E-16 | 5.5 (4.18-7.38) | 15 | 985 |
HR (Hazard Ratio), CI (95% Confidence Interval);
*
The number of models out of 1,000 bootstraps with a p-value < 1E-6 (between 1E-6 and 1E-10) or < 1E-10, respectively.