Table 3.

Pathological findings in the mouse small intestine

	Dose of K-476 (mg/kg)		0	50	100	200	400
K-476	Number of evaluated animals		5	1	1	5	5
	Jejunum	Mucosal epithelium desquamation	0	0	0	0	2
		Mononuclear cell infiltration	0	0	0	0	2
		Hyperplasia/Regeneration	0	0	0	0	2
		Atrophy	0	0	0	0	4
	Ileum	Mucosal epithelium abrasion	0	0	0	0	3
		Mononuclear cell infiltration	0	0	0	0	4
		Atrophy	0	0	0	0	4
K-476/anti-PD-L1	Number of evaluated animals		5	0	2	5	5
	Jejunum	Mucosal epithelium desquamation	0	0	0	0	1
		Mononuclear cell infiltration	0	0	0	0	1
		Hyperplasia/Regeneration	0	0	0	0	2
		Edema	0	0	0	0	1
		Atrophy	0	0	0	0	1
	Ileum	Mucosal epithelium abrasion	0	0	0	0	2
		Mononuclear cell infiltration	0	0	0	0	2
		Hyperplasia/Regeneration	0	0	0	0	1
		Atrophy	0	0	0	0	2

Describes the number of animals with pathological findings among the evaluated animals.