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. 2021 Jan 27;11:2372. doi: 10.1038/s41598-021-81650-5

Figure 1.

Figure 1

NCS1-WT and -KO mice exhibit mostly similar thermal sensation. (A) Compared to male NCS1-WT mice, male NCS1-KO mice displayed a shorter escape latency in a hot plate test only at 50 °C (2-way ANOVA, Factor genotype, p = 0.03, followed by multiple comparison test with Sidak’s correction, temperature 50° C, p = 0.03). No differences were observed between female NCS1-WT and NCS1-KO mice (2-way ANOVA, Factor genotype, p = 0.75). No differences were found at any temperature between NCS1-WT and NCS1-KO mice in the (B) cold plate test [2-way ANOVA (male), Factor genotype, p = 0.13; 2-way ANOVA (female), Factor genotype, p = 0.66] and (C) tail flick test [2-way ANOVA (male), Factor genotype, p = 0.81; 2-way ANOVA (female), Factor genotype, p = 0.21]. Error bars show SD. Male NCS1-WT: n = 15, male NCS1-KO: n = 18, female NCS1-WT: n = 15, female NCS1-KO: n = 23.