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. 2017 Jan 2;25(1):65–73. doi: 10.3727/096504016X14719078133366

Figure 5.

Figure 5

Overexpression of FOXO reverses the effects of the miR-142-5p inhibitor on cell viability and cell apoptosis. After transfection with the miR-142-5p inhibitor, the expression of FOXO1 and FOXO3 was overexpressed, and then the cell viability and cell apoptosis were analyzed. (A, B) The cell viability in both HepG2 and SMMC-7721 cells was significantly increased by the miR-142-5p inhibitor, but these effects were reversed by overexpression of FOXO. (C, D) The percentages of apoptotic cells in both HepG2 and SMMC-7721 cells were markedly decreased by the miR-142-5p inhibitor, but these effects were reversed by overexpression of FOXO. miR, microRNA; FOXO, Forkhead box, class O.*p < 0.05 compared to the control group.