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Knockdown of SOX9 inhibited cell growth and invasion by suppressing the Wnt/β-catenin signaling in PTC cells. Western blot measurement of β-catenin, cyclin D1, and c-Myc expression in siRNA-SOX9-transfected TPC-1 (A) and BCPAP cells (C); relative expression of β-catenin, cyclin D1, and c-Myc in TPC-1 (B) and BCPAP cells (D) was quantified using Image-Pro Plus 6.0 software after normalization with β-actin. Data represent mean ± SD from three independent experiments. *p < 0.05.
