Table 3. Multivariate analysis for type 2 endotype (defined as criterion No.1: IgE > 150 and/or BE > 300 and/or FeNO > 25) in severe asthmatic patients.

Variable			OR	95% CI	P value
Sex (male vs. female)			1.28	0.96–1.69	0.087
BMI (< 25 vs. ≥ 25)			1.82	1.37–2.42	0.001
Age (yr)
	41–60 vs. < 40		1.23	0.81–1.89	0.329
	> 60 vs. < 40		1.69	1.08–2.65	0.022
Age of onset (vs. early < 12)
	Intermediate (12–40)		1.39	0.91–2.10	0.122
	Late (> 40)		1.89	1.17–3.04	0.009
		(trend)			0.008

IgE, immunoglobulin E; BE, blood eosinophils; FeNO, fractional exhaled nitric oxide; OR, odds ratio; CI, confidence interval; BMI, body mass index.