Table 1.
Baseline clinicopathological characteristics of the study cohorts.
| Characteristics | Training Cohort | Validation Cohort | Double-blind Cohort | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BPD | ADC | SCC | SCLC | BPD | ADC | SCC | SCLC | BPD | ADC | SCC | SCLC | |
| n | 40 | 48 | 45 | 30 | 33 | 32 | 32 | 21 | 36 | 31 | 32 | 21 |
| Age, y, mean ± SD | 53.4± 15.5 |
59.1± 11.0 |
64.0.± 8.9 |
57.0± 11.8 |
52.7± 15.9 |
60.1± 9.2 |
63.3± 6.8 |
60.4± 8.8 |
54.1± 13.9 |
55.3± 10.0 |
66.3± 8.6 |
57.3± 9.0 |
| Sex | ||||||||||||
| Male/Female | 29/11 | 28/20 | 42/3 | 26/4 | 20/13 | 13/19 | 32/0 | 15/6 | 23/13 | 14/17 | 30/2 | 18/3 |
| Pathological (AJCC) a | ||||||||||||
| I+II | 5 | 9 | 8 | 14 | 9 | 6 | ||||||
| III+IV | 34 | 21 | 19 | 14 | 18 | 19 | ||||||
| LD | 10 | 8 | 12 | |||||||||
| ED | 11 | 9 | 9 | |||||||||
| Unknown | 9 | 15 | 9 | 5 | 4 | 4 | 4 | 7 | 0 | |||
| Tumor (T) | ||||||||||||
| T1+T2 | 15 | 15 | 2 | 15 | 23 | 1 | 7 | 13 | 1 | |||
| T3+T4 | 19 | 14 | 1 | 11 | 4 | 4 | 20 | 10 | 3 | |||
| TX | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |||
| Unknown | 11 | 15 | 27 | 5 | 5 | 16 | 4 | 9 | 17 | |||
| Node (N) | ||||||||||||
| N0 | 10 | 7 | 2 | 8 | 9 | 2 | 11 | 5 | 0 | |||
| N1 | 3 | 5 | 0 | 5 | 6 | 0 | 3 | 4 | 0 | |||
| N2 | 7 | 11 | 1 | 4 | 4 | 1 | 7 | 9 | 1 | |||
| N3 | 13 | 7 | 0 | 8 | 8 | 2 | 6 | 5 | 3 | |||
| NX | 4 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | |||
| Unknown | 11 | 15 | 27 | 5 | 5 | 16 | 4 | 9 | 17 | |||
| Metastasis (M) | ||||||||||||
| M0 | 13 | 17 | 2 | 10 | 21 | 2 | 14 | 15 | 1 | |||
| M1+M2 | 24 | 13 | 1 | 17 | 6 | 3 | 13 | 8 | 3 | |||
| Unknown | 11 | 15 | 27 | 5 | 5 | 16 | 4 | 9 | 17 | |||
aAJCC, American Joint Committee on Cancer staging system (7th edition); BPD, benign pulmonary disease; ADC, adenocarcinoma; SCC, squamous carcinoma; SCLC, small cell lung cancer; LD, limited stage of small cell lung cancer; ED, extensive stage of small cell lung cancer.