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. 2021 Jan 27;12:636. doi: 10.1038/s41467-020-20608-z

Fig. 4. SARS-CoV-2 Nsp15 active site superimposition with metal-independent endoribonucleases.

Fig. 4

a SARS-CoV-2 Nsp15 catalytic residues are shown as sticks (PDB ID 7K0R; beige) along with its bound 5′-UMP nucleotide (cyan) and model 3′-phosphate (3′-PO4). b Bos taurus (Bt) RNase A (PDB ID: 1O0N; magenta) bound to 3′-UMP (cyan)25, c Homo sapiens (Hs) angiogenin (PDB ID: 1HBY; brown) bound to 3′-phosphate (3′-PO4)44, d SARS-CoV-1 Nsp15 (PDB ID: 2H85; orange)45, e MERS Nsp15 (PDB ID: 5YVD; green)4, and f PRRSV Nsp11 (PDB ID: 5EYI; gray)46 are superimposed with the SARS-CoV-2 Nsp15 active site.