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. 2021 Jan 27;12:612. doi: 10.1038/s41467-021-20902-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a–d 3DSIM images of the MT networks stained with alpha-tubulin antibody for both young (P45) and aged (20-month old) mice. a, b ANKS1A^+/+ set, n = 6 cells from 2 mice; ANKS1A^−/−, n = 5 cells from 2 mice. c, d ANKS1A^+/+ set, n = 9 cells from 3 mice; ANKS1A^−/−, n = 9 cells from 3 mice. Scale bar for a, c, 5 μm. e A representative TEM image illustrating the intermediate filament and microtubule. Scale bar, 500 nm. f–j 3D reconstruction of the microtubule and intermediate lattice. The image of the microtubules (green) and intermediate filament (orange) was reconstructed and superimposed on a single plane. For g, h (P45 mice), ANKS1A^+/+ set, n = 10 cells from 2 mice; ANKS1A^−/−, n = 10 cells from 2 mice. For j, k (20-month-old mice), ANKS1A^+/+ set, n = 9 cells from 2 mice; ANKS1A^−/−, n = 9 cells from 2 mice. Scale bar for f, i, 500 nm.