Table 2.
Hazard ratios and 95% CI for composite events.
| All-cause death or readmission for HF | ||
|---|---|---|
| HR (95% CI) | P value | |
| Model 1 | ||
| Low iron (serum Fe < 62 µg/dL) | 1.956 (1.570–2.444) | < 0.0001 |
| Model 2 | ||
| Low iron (serum Fe < 62 µg/dL) | 1.739(1.392–2.179) | < 0.0001 |
| Age, year | 1.038 (1.027–1.049) | < 0.0001 |
| Male | 1.408 (1.128–1.757) | 0.0023 |
| Model 3 | ||
| Low iron (serum Fe < 62 µg/dL) | 1.454 (1.149–1.847) | 0.0020 |
| Age, year | 1.033 (1.022–1.044) | < 0.0001 |
| Male | 1.378 (1.100–1.726) | 0.0053 |
| Hemoglobin, g/dL | 0.856 (0.800–0.916) | < 0.0001 |
| eGFR, mL/min/1.73 m2 | 1.005 (0.999–1.010) | 0.1004 |
| Plasma BNP, 100 pg/mL | 1.028 (1.006–1.048) | 0.0082 |
| LVEF, % | 0.997 (0.989–1.004) | 0.3747 |
| Model 4 | ||
| Low iron (serum Fe < 62 µg/dL) | 1.500 (1.128–1.976) | 0.0044 |
| Age, year | 1.034 (1.023–1.047) | < 0.0001 |
| Male | 1.399 (1.108–1.766) | 0.0047 |
| Hemoglobin, g/dL | 0.866 (0.807–0.928) | < 0.0001 |
| eGFR, mL/min/1.73 m2 | 1.005 (0.999–1.011) | 0.0930 |
| Plasma BNP, 100 pg/Ll | 1.026 (1.004–1.047) | 0.0158 |
| LVEF, % | 0.996 (0.988–1.004) | 0.3244 |
| Ferritin, µg/L | 1.000 (1.000–1.001) | 0.5761 |
| TSAT, % | 1.001 (0.990–1.009) | 0.8392 |
| Model 5 | ||
| Low iron (serum Fe < 62 µg/dL) | 1.487 (1.074–2.059) | 0.0169 |
| Hemoglobin, g/dL | 0.856 (0.804–0.913) | < 0.0001 |
| MCV, fl | 1.038 (1.020–1.057) | < 0.0001 |
| Ferritin, µg/L | 1.000 (0.999–1.000) | 0.4769 |
| TSAT, % | 0.998 (0.986–1.011) | 0.7758 |
| Transferrin, mg/dL | 1.001 (0.998–1.004) | 0.5442 |
HF heart failure; eGFR estimated glomerular filtration rate; BNP B-type natriuretic peptide; LVEF, left ventricular ejection fraction; TSAT transferrin saturation; MCV mean corpuscular volume; HR hazard ratio; CI confidence interval.